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Toxicol Appl Pharmacol. 2016 Jan 1;290:86-97. doi: 10.1016/j.taap.2015.11.016. Epub 2015 Nov 26.

Experimental models of hepatotoxicity related to acute liver failure.

Author information

1
Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.
2
Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: mvinken@vub.ac.be.
3
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, United States.

Abstract

Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure.

KEYWORDS:

Acetaminophen; Acute liver failure; Concanavalin A; D-galactosamine; Fas ligand; Hepatotoxicity

PMID:
26631581
PMCID:
PMC4691574
DOI:
10.1016/j.taap.2015.11.016
[Indexed for MEDLINE]
Free PMC Article

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