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Curr Protoc Mouse Biol. 2015 Dec 2;5(4):331-358. doi: 10.1002/9780470942390.mo150068.

Assessing Cognition in Mice.

Author information

1
Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
2
German Mouse Clinic, Helmholtz Zentrum München, Munich, Germany.
3
Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
4
Technical University of Munich, Department of Experimental Genetics, Munich, Germany.
5
German Center for Diabetes Research, Neuherberg, Germany.
6
Technical University of Munich, Department of Developmental Genetics, Munich, Germany.
7
German Center for Neurodegenerative Diseases, Munich, Germany.
8
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Abstract

Genetically modified mouse models have proven useful to study learning and memory processes and the neurocircuitry and molecular mechanisms involved, as well as to develop therapies for diseases involving cognitive impairment. A variety of tests have been developed to measure cognition in mice, and here we present those established and regularly used in the German Mouse Clinic. The test paradigms have been carefully chosen according to reliability of results and disease relevance of the cognitive functions assessed. Further criteria were time efficiency and ease of application. All tests assess slightly different but also overlapping or interacting aspects of learning and memory so that they can be used to complement each other in a comprehensive assessment of cognitive function. The five protocols described are for spontaneous alternation in the Y-maze, social discrimination, object recognition, automated assessment of learning and memory using the IntelliCage, and olfactory discrimination learning.

KEYWORDS:

IntelliCage; Y-maze; object recognition; olfactory discrimination learning; social discrimination

PMID:
26629775
DOI:
10.1002/9780470942390.mo150068
[Indexed for MEDLINE]

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