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Arch Intern Med. 1989 Jul;149(7):1514-20.

The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.

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1
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9030.

Abstract

The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia.

PMID:
2662932
[Indexed for MEDLINE]
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