Format

Send to

Choose Destination
Int J Clin Exp Med. 2015 Sep 15;8(9):15910-9. eCollection 2015.

The effect of radish sourced 4-(Methylthio)-3-butenyl isothiocyanate on ameliorating the severity of high fat diet inducted nonalcoholic fatty liver disease in rats.

Author information

1
College of Food Science and Nutritional Engineering, China Agricultural University Beijing 100000, P. R. China.
2
College of Food Science and Nutritional Engineering, China Agricultural University Beijing 100000, P. R. China ; Institute of Cancer, Xinqiao Hospital, Third Military medical University Chongqing 404100, China.

Abstract

The aim of this study is to develop a high fat diet and over nutrition induced nonalcoholic fatty liver disease(NAFLD) in rat, and to investigate the effect of 4-(Methylthio)-3-butenyl isothiocyanate (MTBITC) on ameliorating the NAFLD. Twenty Sprague-Dawley (SD) rats were equally divided into 4 groups (C, M, E1 & E2). Control group (C) were treated with standard restricted diet; Model group (M) were given high fat liquid diet ad libitum; Experimental group (E1 & E2) were treated with high fat liquid diet ad libitum and MTBITC by gavage. The experiment last 9 weeks, and serum chemistry and liver histology were assessed. The rats of M group showed severe lipid deposition and peroxidation in liver. When compared with group C, group M also showed significantly higher serum concentration of low-density lipoprotein, tumor necrosis factor-α and glucose. Histopathologic sections demonstrated lipid accumulation and macrovascular steatosis with ballooning degeneration in the livers of M. Group E2 presented significantly better conditions when assessed based on the parameters of NAFLD. The data suggested that MTBITC might significantly attenuate fat liquid diet induced NAFLD.

KEYWORDS:

4-(Methylthio)-3-butenyl isothiocyanate; Chinese white radish; Nonalcoholic fatty liver disease; antioxidative stress; phytochemical

PMID:
26629094
PMCID:
PMC4658983

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center