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Int J Clin Exp Med. 2015 Sep 15;8(9):15173-81. eCollection 2015.

Prognostic significance of peripheral monocytic myeloid-derived suppressor cells and monocytes in patients newly diagnosed with diffuse large b-cell lymphoma.

Author information

1
Department of Hematology, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu Province, P R. China.
2
Department of Cardiac Surgery, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu Province, P R. China.
3
Department of Pediatric, The First Hospital of Lanzhou Lanzhou 730050, Gansu Province, P R. China.
4
Institute of Urology, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu Province, P R. China.
5
Institute of Hematology, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu Province, P R. China.
6
Institute of Urology, Key Laboratory of Urological Diseases in Gansu Province, Gansu Nephro-Urological Clinical Center, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu Province, P R. China.

Abstract

OBJECTIVE:

The revised International Prognostic Index (R-IPI) aids in predicting the prognosis of patients with diffuse large B cell lymphoma (DLBCL), but R-IPI yields no significant differences in assessing different subtypes of DLBCL. It is necessary to identify patients with a high-risk of DLBCL and alternative therapy should be delivered as early as possible.

METHODS:

In total, 144 patients newly diagnosed with DLBCL including 63 GCB-DLBCL and 81 non-GCB-DLBCL and 30 healthy controls were enrolled. Peripheral monocytic myeloid-derived suppressor cells (M-MDSC) (CD14(+)HLA(-)DR(low/-)) were detected by flow cytometry and the percentage of monocytes (MΦ) was evaluated by completed blood count (CBC). The correlation between M-MDSC% and MΦ% was statistically analyzed.

RESULTS:

Compared with healthy controls, significant increase was observed in M-MDSC% and MΦ% in DLBCL patients (both P<0.001). Significant difference of M-MDSC% was found between GCB-DLBCL and non-GCB-DLBCL patients in both poor (P<0.001) and very good groups (P=0.03), whereas no statistical significance in the good group (P>0.05). The MΦ% in non-GCB-DLBCL patients was significantly higher than that in GCB-DLBCL counterparts merely in the poor group (P<0.001). Positive correlation was noted between MΦ% and M-MDSC in all DLBCL patients rather than in healthy controls (r=0.227 P=0.229).

CONCLUSION:

The percentage of peripheral MΦ was positively correlated with M-MDSC% in patients with different subtypes and risks of DLBCL. Peripheral MΦ% and M-MDSC% combined with R-IPI score may be useful for predicting the prognosis of patients newly-diagnosed with DLBCL.

KEYWORDS:

Monocytic myeloid-derived suppressor cell; diffuse large B-cell lymphoma; monocyte; revised international prognostic index

PMID:
26629001
PMCID:
PMC4658890

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