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Cell Rep. 2015 Dec 15;13(10):2287-96. doi: 10.1016/j.celrep.2015.10.076. Epub 2015 Nov 25.

Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine.

Author information

1
Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297, 33076 Bordeaux, France; Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
2
Université de la Méditerranée, UMR S901, Aix-Marseille 2, 13009 Marseille, France; INSERM-INMED, UMR 901, 13009 Marseille, France.
3
Institut du Fer a Moulin, 75005 Paris, France; INSERM/UPMC, UMR-S 839, 75005 Paris, France.
4
"G. Minardi" Cognitive Neuroscience Laboratory, Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy.
5
CNRS, UMR8246 NPS, 75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UM119, NPS, 75005 Paris, France; INSERM, U1130 NPS, 75005 Paris, France.
6
Université de Bordeaux, INCIA, BP31, 33076 Bordeaux, France; CNRS, UMR5287 INCIA, 33076 Bordeaux, France.
7
Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297, 33076 Bordeaux, France; Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France. Electronic address: francois.georges@u-bordeaux.fr.

Abstract

The ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits and synaptic mechanisms by which vSUB alters the excitability of dopamine neurons is a necessary step to understand the motor changes induced by cocaine. Here, we report that high-frequency stimulation of the vSUB (HFSvSUB) over-activates ventral tegmental area (VTA) dopamine neurons in vivo and triggers long-lasting modifications of synaptic transmission measured ex vivo. This potentiation is caused by NMDA-dependent plastic changes occurring in the bed nucleus of the stria terminalis (BNST). Finally, we report that the modification of the BNST-VTA neural circuits induced by HFSvSUB potentiates locomotor activity induced by a sub-threshold dose of cocaine. Our findings unravel a neuronal circuit encoding behavioral effects of cocaine in rats and highlight the importance of adaptive modifications in the BNST, a structure that influences motivated behavior as well as maladaptive behaviors associated with addiction.

PMID:
26628379
DOI:
10.1016/j.celrep.2015.10.076
[Indexed for MEDLINE]
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