Format

Send to

Choose Destination
J Pediatric Infect Dis Soc. 2014 Jun;3(2):168-71. doi: 10.1093/jpids/pit014. Epub 2013 Apr 5.

Azithromycin Inhibits Macrophage Tumor Necrosis Factor Secretion in Response to Both Azithromycin-Susceptible and Azithromycin-Resistant Pneumococci.

Author information

1
Children's Foundation Research Institute at Le Bonheur Children's Hospital; Divisions of Pediatric Critical Care Medicine.
2
Children's Foundation Research Institute at Le Bonheur Children's Hospital; Divisions of.
3
Children's Foundation Research Institute at Le Bonheur Children's Hospital; Divisions of Neonatology.
4
Children's Foundation Research Institute at Le Bonheur Children's Hospital; Divisions of Pediatric Critical Care Medicine Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis.
5
Children's Foundation Research Institute at Le Bonheur Children's Hospital; Divisions of Pediatric Infectious Diseases, Department of Pediatrics.

Abstract

We studied the effect of azithromycin (AZM) on macrophage responses to pneumococci. We found that exposure of pneumococci to AZM led to reduced tumor necrosis factor (TNF) secretion by macrophages; this effect was observed in response to both AZM-susceptible and AZM-resistant (AZM-R) pneumococci.

KEYWORDS:

TNF; ampicillin; azithromycin; macrophage; pneumococci

PMID:
26625370
DOI:
10.1093/jpids/pit014

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center