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Biosci Biotechnol Biochem. 2016;80(4):798-800. doi: 10.1080/09168451.2015.1116922. Epub 2015 Dec 1.

Lactococcus lactis subsp. lactis JCM 5805 activates natural killer cells via dendritic cells.

Author information

1
a Central Laboratories for Key Technologies , Kirin Co., Ltd. , Yokohama , Japan.

Abstract

Lactococcus lactis subsp. lactis JCM 5805 (JCM5805) has been shown to stimulate plasmacytoid dendritic cells (pDC). Here, we investigated the effect of JCM5805 on NK cells. In vitro studies suggested that JCM5805 activated natural killer (NK) cells via dendritic cells including pDC. Furthermore, the oral administration of JCM5805 enhanced the cytotoxic activity of NK cells.

KEYWORDS:

Lactococcus lactis; dendritic cells; natural killer cells

PMID:
26623718
DOI:
10.1080/09168451.2015.1116922
[Indexed for MEDLINE]

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