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ACS Nano. 2016 Jan 26;10(1):822-31. doi: 10.1021/acsnano.5b05931. Epub 2015 Dec 4.

Biodegradable Photonic Melanoidin for Theranostic Applications.

Author information

1
Medical Device Research Center, Samsung Biomedical Research Institute, Samsung Advanced Institute of Technology (SAIT), Samsung Electronics Company Ltd. , Seoul 135-710, Korea.
2
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital , 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, United States.

Abstract

Light-absorbing nanoparticles for localized heat generation in tissues have various biomedical applications in diagnostic imaging, surgery, and therapies. Although numerous plasmonic and carbon-based nanoparticles with strong optical absorption have been developed, their clearance, potential cytotoxicity, and long-term safety issues remain unresolved. Here, we show that "generally regarded as safe (GRAS)" melanoidins prepared from glucose and amino acid offer a high light-to-heat conversion efficiency, biocompatibility, biodegradability, nonmutagenicity, and efficient renal clearance, as well as a low cost for synthesis. We exhibit a wide range of biomedical photonic applications of melanoidins, including in vivo photoacoustic mapping of sentinel lymph nodes, photoacoustic tracking of gastrointestinal tracts, photothermal cancer therapy, and photothermal lipolysis. The biodegradation rate and renal clearance of melanoidins are controllable by design. Our results confirm the feasibility of biodegradable melanoidins for various photonic applications to theranostic nanomedicines.

KEYWORDS:

biodegradable; melanoidin; photoacoustic; photothermal; theranostics

PMID:
26623481
DOI:
10.1021/acsnano.5b05931
[Indexed for MEDLINE]

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