New α-glucosidase inhibiting anthracenone from the barks of Harungana madagascariensis Lam

Ismail B Onajobi; Achyut Adhikari; Shabbir Hussain; Kulsoom Javaid; Obasola E Fagade; I A Oladosu

doi:10.1080/14786419.2015.1115998

New α-glucosidase inhibiting anthracenone from the barks of Harungana madagascariensis Lam

Nat Prod Res. 2016 Nov;30(22):2507-2513. doi: 10.1080/14786419.2015.1115998. Epub 2015 Nov 30.

Authors

Ismail B Onajobi^{1

2}, Achyut Adhikari², Shabbir Hussain², Kulsoom Javaid², Obasola E Fagade³, I A Oladosu⁴

Affiliations

¹ a Department of Microbiology , Olabisi Onabanjo University , Ago-Iwoye , Nigeria.
² b H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
³ c Environmental and Biotechnology Unit, Department of Microbiology , University of Ibadan , Ibadan , Nigeria.
⁴ d Department of Chemistry , University of Ibadan , Ibadan , Nigeria.

PMID: 26621758
DOI: 10.1080/14786419.2015.1115998

Abstract

Two new 10-hydroxy-9(10H)-anthracenone, madagascenone A (1) and B (2), were isolated from the barks of Harungana madagascariensis Lam. The structures of the compounds were determined using 1D- and 2D-NMR and mass spectroscopic techniques. Both of the compounds showed an in vitro α-glucosidase inhibition with IC₅₀ = 69.9 ± 4.21 and 122.3 ± 1.13 μM, respectively, more potent than the standard acarbose (IC₅₀ = 840 ± 1.23 μM).

Keywords: Harungana madagascariensis; madagascenone A and B; α-glucosidase inhibition.