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Eur J Nutr. 2017 Mar;56(2):621-634. doi: 10.1007/s00394-015-1106-8. Epub 2015 Nov 30.

Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status.

Author information

1
Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, Ernst Grube Strasse 40, 06120, Halle/Saale, Germany.
2
Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120, Halle/Saale, Germany.
3
Department of Clinical Medicine, University of Bergen, Postbox 7804, 5020, Bergen, Norway.
4
Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120, Halle/Saale, Germany. gabriele.stangl@landw.uni-halle.de.

Abstract

PURPOSE:

The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D3 for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D3 dose impacts cardiovascular risk markers of adults during the winter months.

METHODS:

The study was conducted in Halle (Saale), Germany (51o northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April). A total of 105 apparently healthy subjects (male and female, 20-71 years old) were included. Subjects were randomly allocated to two groups. One group received a daily 20-µg vitamin D3 dose (n = 54), and the other group received a placebo (n = 51) for 12 weeks. Outcome measures included blood pressure, heart rate, concentrations of renin, aldosterone, serum lipids and vascular calcification markers, and haematologic variables such as pro-inflammatory monocytes.

RESULTS:

Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D3 supplementation, although serum 25-hydroxyvitamin D3 increased from 38 ± 14 to 73 ± 16 nmol/L at week 12. The placebo and vitamin D groups did not differ in their final cardiovascular risk profile.

CONCLUSION:

Daily supplementation of 20 µg vitamin D3 during winter is unlikely to change cardiovascular risk profile.

KEYWORDS:

Adults; Cardiovascular risk; Monocyte subsets; Supplementation; Vitamin D3

PMID:
26621634
DOI:
10.1007/s00394-015-1106-8
[Indexed for MEDLINE]

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