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Adv Exp Med Biol. 2015;883:255-70. doi: 10.1007/978-3-319-23603-2_14.

Structural Aspects of Bacterial Outer Membrane Protein Assembly.

Author information

1
Department of Biochemistry, University of Toronto, Medical Science Building, Rm. 5366, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. charles.calmettes@utoronto.ca.
2
Department of Biochemistry, University of Toronto, Medical Science Building, Rm. 5366, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. andrew.judd@mail.utoronto.ca.
3
Department of Biochemistry, University of Toronto, Medical Science Building, Rm. 5366, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. trevor.moraes@utoronto.ca.

Abstract

The outer membrane of Gram-negative bacteria is predominantly populated by β-Barrel proteins and lipid anchored proteins that serve a variety of biological functions. The proper folding and assembly of these proteins is essential for bacterial viability and often plays a critical role in virulence and pathogenesis. The β-barrel assembly machinery (Bam) complex is responsible for the proper assembly of β-barrels into the outer membrane of Gram-negative bacteria, whereas the localization of lipoproteins (Lol) system is required for proper targeting of lipoproteins to the outer membrane.

KEYWORDS:

Bam machinery; Lol pathway; Omp85 family; Outer membrane biogenesis; Protein trafficking

PMID:
26621472
DOI:
10.1007/978-3-319-23603-2_14
[Indexed for MEDLINE]

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