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Eur J Appl Physiol. 2016 Mar;116(3):471-80. doi: 10.1007/s00421-015-3301-y. Epub 2015 Nov 30.

Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations.

Author information

1
University Hospitals Centre for Health Research (UCSF), Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark. ju@ucsf.dk.
2
Department of Nutrition, Exercise and Sports, Copenhagen Centre for Team Sport and Health, University of Copenhagen, Nørre Allé 51, Copenhagen, 2200, Denmark.
3
Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
4
Department of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, 1014, Denmark.
5
Department of Clinical Biochemistry, Rigshospitalet, Research Center for Ageing and Osteoporosis, Ndr. Ringvej 57, Glostrup, 2600, Denmark.
6
Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, Odense, 5000, Denmark.
7
Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
8
Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
9
National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, 2100, Denmark.
10
Physical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, 9220, Aalborg, Denmark.
11
Department of Oncology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
12
University Hospitals Centre for Health Research (UCSF), Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
13
Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, PO Box 2099, 1014, Copenhagen K, Denmark.
14
Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, UK.

Abstract

PURPOSE:

To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT).

METHODS:

This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance.

RESULTS:

In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8-46.9 g, p = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p < 0.01). The number of decelerations correlated to the increase in leg BMC (r = 0.65, p = 0.012). No between-group differences were observed for the remaining outcomes.

CONCLUSION:

Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT.

TRIAL REGISTRATION:

ClinicalTrials.gov: NCT01711892.

KEYWORDS:

Association football; Bone mineral content (BMC); Bone turnover markers (BTM); Exercise intensity; GPS; Prostate cancer

PMID:
26620651
DOI:
10.1007/s00421-015-3301-y
[Indexed for MEDLINE]

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