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Nature. 1989 Jun 29;339(6227):679-84.

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2.

Author information

1
Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.

Abstract

Actively transcribing eukaryotic RNA polymerase II is highly phosphorylated on its repetitive carboxyl-terminal domain. We have isolated a protein kinase that phosphorylates serine residues in this repetitive domain. A component of this kinase is cdc2, the product of a cell-cycle control gene previously shown to be a component of M-phase-promoting factor and M-phase-specific histone H1 kinase. This observation suggests a role for the cdc2 protein kinase in transcriptional regulation.

PMID:
2662013
DOI:
10.1038/339679a0
[Indexed for MEDLINE]

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