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Semin Cardiothorac Vasc Anesth. 2016 Jun;20(2):158-62. doi: 10.1177/1089253215619235. Epub 2015 Nov 29.

Transfemoral Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease in Child's Class C Liver Disease Prior to Orthotopic Liver Transplantation: A Case Report.

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University of Colorado Denver, Aurora, Colorado, USA
University of Colorado Denver, Aurora, Colorado, USA.


The American Association for the Study of Liver Diseases practice guidelines list severe cardiac disease as a contraindication to liver transplantation. Transcatheter aortic valve replacement has been shown to decrease all-cause mortality in patients with severe aortic stenosis who are not considered candidates for surgical aortic valve replacement. We report our experience of liver transplantation in a patient with severe aortic stenosis and moderate aortic insufficiency who underwent transcatheter aortic valve replacement with Child-Pugh Class C disease at a Model For End-Stage Liver Disease score of 29. The patient had a difficult post procedure course that was successfully medically managed. After liver transplantation the patient was discharged to home on postoperative day 11. The combination of cardiac disease and end stage liver disease is challenging but these patients can have a successful outcome despite very severe illness.


aortic valve replacement; cardiac anesthesia; cardiac surgery; coagulopathy; heparin; platelet function

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