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Nutr Diabetes. 2015 Nov 30;5:e185. doi: 10.1038/nutd.2015.35.

The application of omics technologies in the functional evaluation of inulin and inulin-containing prebiotics dietary supplementation.

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Faculty of Environment and Information Studies, Keio University, Fujisawa, Japan.
Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan.
Graduate School of Media and Governance, Keio University, Fujisawa, Japan.


Inulin, a natural renewable polysaccharide resource produced by various plants in nature, has been reported to possess a significant number of diverse pharmaceutical and food applications. Recently, there has been rapid progress in high-throughput technologies and platforms to assay global mRNA, proteins, metabolites and gut microbiota. In this review, we will describe the current status of utilizing omics technologies of elucidating the impact of inulin and inulin-containing prebiotics at the transcriptome, proteome, metabolome and gut microbiome levels. Although many studies in this review have addressed the impact of inulin comprehensively, these omics technologies only enable us to understand physiological information at each different stage of mRNA, protein, metabolite and gut microbe. We believe that a synergistic approach is vital in order to fully illustrate the intricate beauty behind the relatively modest influence of food factors like inulin on host health.

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