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Hum Vaccin Immunother. 2016 Apr 2;12(4):937-8. doi: 10.1080/21645515.2015.1112475. Epub 2015 Nov 30.

Persistence of Yellow Fever vaccine-induced antibodies after cord blood stem cell transplant.

Author information

1
a Department of Infectious and Parasitic Diseases , University of Sao Paulo Medical School , Sao Paulo , Brazil.
2
b Hospital Sirio-Libanes , Sao Paulo , Brazil.
3
c Fundação Oswaldo Cruz , Rio de Janeiro , Brazil.
4
d Fundacao Pro-Sangue Hemocentro de Sao Paulo , Sao Paulo , Brazil.
5
e Division of Clinic Immunology and Allergy , University of Sao Paulo Medical School , Sao Paulo , Brazil.

Abstract

We report the case of a cord blood haematopoietic stem cell transplant recipient who was vaccinated for Yellow Fever (YF) 7 days before initiating chemotherapy and had persistent YF antibodies more than 3 years after vaccination. Since the stem cell donor was never exposed to wild YF or to the YF vaccine, and our patient was not exposed to YF or revaccinated, this finding strongly suggests the persistence of recipient immunity. We briefly discuss potential consequences of incomplete elimination of recipient's leukocytes following existing haematopoietic cancer treatments.

KEYWORDS:

cord blood stem cell transplant; immunosuppression; vaccine; yellow fever

PMID:
26618995
PMCID:
PMC4962932
DOI:
10.1080/21645515.2015.1112475
[Indexed for MEDLINE]
Free PMC Article

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