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Dermatol Surg. 2015 Dec;41 Suppl 1:S325-32. doi: 10.1097/DSS.0000000000000548.

Patient Satisfaction and Efficacy of Full-Facial Rejuvenation Using a Combination of Botulinum Toxin Type A and Hyaluronic Acid Filler.

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*Medikas, Somerset, United Kingdom; †Private Practice, Metz, France; ‡Riverbanks Clinic, Bedfordshire, United Kingdom; §Clínica Moisés Amselem, Madrid, Spain; ‖Clínica Dermatológica Internacional Skinlogic, Madrid, Spain; ¶Galderma R&D, Sophia Antipolis, France; #Freelance office, Epinay-Sous-Sénart, France; **AESTHETICS, Bordeaux, France.



Combination treatments using hyaluronic acid (HA) fillers and botulinum toxin Type A (BoNT-A) are common in aesthetic medicine; however, this has been evaluated in only a few clinical studies.


To evaluate subject satisfaction, efficacy, and safety of BoNT-A (Speywood Unit; s.U) and a range of HA fillers for full-facial aesthetic rejuvenation.


A 6-month, multicenter, open-label clinical study, using BoNT-A (s.U) and 5 HA fillers to treat up to 13 facial zones. Subject satisfaction questionnaires were administered 3 weeks and 6 months after the last injection. Global aesthetic improvement and improvement on each treated zone as well as safety were evaluated.


A high level of satisfaction was achieved throughout the study, with 96.5% of subjects at least satisfied with the full-facial aesthetic outcome at 3 weeks, and 92.9% at 6 months. More than 91% considered the treatment outcome to meet or surpass their expectations, and more than 94% would recommend the treatment to others. At Week 3, subject and investigator assessment showed aesthetic improvement for all subjects. The treatment was well tolerated.


The combination of BoNT-A (s.U) and HA fillers results in high patient satisfaction and in an overall improvement of aesthetic outcomes and quality of life.

[Indexed for MEDLINE]

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