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Int J Clin Exp Pathol. 2015 Sep 1;8(9):10585-94. eCollection 2015.

Immunohistochemical evaluation of stem cell markers and signal transducer and activator of transcription 6 (STAT6) in solitary fibrous tumors.

Author information

1
Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi, Xinjiang, China.
2
Department of Public Health, Shihezi University School of Medicine Shihezi, Xinjiang, China.
3
Department of Pathology, People's Hospital of Xinjiang Autonomous Region Urumqi, Xinjiang, China.

Abstract

Solitary fibrous tumors (SFT) are fibroblastic, ubiquitous mesenchymal tumors. Although several SFT studies have been conducted, the cell of origin of SFT remains controversial and reliable diagnostic markers are needed for SFT identification for proper prognosis and therapeutics. To analyze the immunophenotype of SFT for the identification of specific diagnostic markers and the cell of origin of this tumor, we performed an immunohistochemical study of stem cell markers [aldehyde dehydrogenase 1 (ALDH1), CD29, CD44, CD133, and nestin] and signal transducer and activator of transcription 6 (STAT6) in 18 cases of SFT. The results demonstrated that ALDH1 was present in 16 cases (16/18), STAT6 in 13 cases (13/18), CD44 in 8 cases (8/18), and CD29 in 1 case (1/18), whereas CD133 and nestin were absent in all cases (0/18). Our results indicate that combination with ALDH1 and STAT6 can improve the diagnostic value of CD34 for SFT. The immunohistochemical findings for stem cell surface markers indicate that SFT may originate from stem cells and that ALDH1 plays an important role in the development of SFT.

KEYWORDS:

ALDH1; STAT6; Solitary fibrous tumor; immunohistochemistry; stem cell markers

PMID:
26617768
PMCID:
PMC4637583
[Indexed for MEDLINE]
Free PMC Article

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