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Front Microbiol. 2015 Nov 9;6:1226. doi: 10.3389/fmicb.2015.01226. eCollection 2015.

Modulation of Host Biology by Pseudomonas aeruginosa Quorum Sensing Signal Molecules: Messengers or Traitors.

Author information

1
Division of Molecular Microbiology, School of Life Sciences, University of Dundee Dundee, UK.
2
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya Kuala Lumpur, Malaysia.
3
Centre for Bacterial Cell Biology, Medical School, Newcastle University Newcastle upon Tyne, UK ; Interdisciplinary Computing and Complex BioSystems (ICOS) Research Group, School of Computing Science, Newcastle University Newcastle upon Tyne, UK.

Abstract

Bacterial cells sense their population density and respond accordingly by producing various signal molecules to the surrounding environments thereby trigger a plethora of gene expression. This regulatory pathway is termed quorum sensing (QS). Plenty of bacterial virulence factors are controlled by QS or QS-mediated regulatory systems and QS signal molecules (QSSMs) play crucial roles in bacterial signaling transduction. Moreover, bacterial QSSMs were shown to interfere with host cell signaling and modulate host immune responses. QSSMs not only regulate the expression of bacterial virulence factors but themselves act in the modulation of host biology that can be potential therapeutic targets.

KEYWORDS:

N-acyl homoserine lactones; Pseudomonas aeruginosa; Pseudomonas quinolone signal; Quorum sensing; immunomodulation

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