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Dermatol Clin. 2016 Jan;34(1):45-9. doi: 10.1016/j.det.2015.08.005.

Endocrinologic Aspects of Hidradenitis Suppurativa.

Author information

1
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany.
2
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany. Electronic address: christos.zouboulis@klinikum-dessau.de.

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of unknown etiology. The role of hormones in HS remains unclear, but the observation of premenstrual flares, female predominance, and improvement during pregnancy suggest a hormonal/metabolic background. The reported positive effects of antiandrogen therapy supports a possible role of androgens. The predominant onset of the disease years after puberty may indicate a metabolic disorder. Obesity contributes significantly to HS pathogenesis; diabetes, dyslipidemia, the metabolic syndrome, and polycystic ovarian syndrome are among the commonest comorbidities. More studies are required to clarify a potential hormonal dysregulation in HS.

KEYWORDS:

Acne inversa; Androgens; Apocrine glands; Endocrinology; Hidradenitis suppurativa; Hyperandrogenism; Metabolic syndrome; Obesity

PMID:
26617357
DOI:
10.1016/j.det.2015.08.005
[Indexed for MEDLINE]

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