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Chem Commun (Camb). 2016 Jan 25;52(7):1365-8. doi: 10.1039/c5cc08401f.

Enantioselective targeting left-handed Z-G-quadruplex.

Author information

1
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China. xqu@ciac.ac.cn.

Abstract

Herein, we report the first example where an M-enantiomer of a chiral metal complex can selectively stabilize a left-handed G-quadruplex, but its P-enantiomer cannot. The interactions between the chiral metal complexes and the left-handed G-quadruplex were evaluated by UV melting, circular dichroism, isothermal titration calorimetry, gel electrophoresis and NMR titrations.

PMID:
26616287
DOI:
10.1039/c5cc08401f
[Indexed for MEDLINE]

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