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Exp Neurol. 2016 Feb;276:13-21. doi: 10.1016/j.expneurol.2015.11.009. Epub 2015 Nov 23.

Interneurons in the human olfactory system in Alzheimer's disease.

Author information

1
Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain.
2
Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain. Electronic address: Alino.Martinez@uclm.es.

Abstract

The principal olfactory structures display Alzheimer's disease (AD) related pathology at early stages of the disease. Consequently, olfactory deficits are among the earliest symptoms. Reliable olfactory tests for accurate clinical diagnosis are rarely made. In addition, neuropathological analysis postmortem of olfactory structures is often not made. Therefore, the relationship between the clinical features and the underlying pathology is poorly defined. Traditionally, research into Alzheimer's disease has focused on the degeneration of cortical temporal projection neurons and cholinergic neurons. Recent evidence has demonstrated the neurodegeneration of interneuron populations in AD. This review provides an updated overview of the pathological involvement of interneuron populations in the human olfactory system in Alzheimer's disease.

KEYWORDS:

Amyloid-β; Archicortex; Calcium binding protein; Somatostatin; Tau

PMID:
26616239
DOI:
10.1016/j.expneurol.2015.11.009
[Indexed for MEDLINE]

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