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Biochim Biophys Acta. 2016 May;1863(5):1019-26. doi: 10.1016/j.bbamcr.2015.11.022. Epub 2015 Nov 23.

Why do peroxisomes associate with the cytoskeleton?

Author information

1
Max-Planck-Institute of Biophysics, Frankfurt, Germany.
2
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, OX3 9DS Oxford, United Kingdom.
3
Department of Systems Biochemistry, Institute of Biochemistry and Pathobiochemistry, Faculty of Medicine, Ruhr-University Bochum, Germany.
4
Department of Systems Biochemistry, Institute of Biochemistry and Pathobiochemistry, Faculty of Medicine, Ruhr-University Bochum, Germany. Electronic address: wolfgang.schliebs@rub.de.

Abstract

Attachment of peroxisomes to cytoskeleton and movement along microtubular filaments and actin cables are essential and highly regulated processes enabling metabolic efficiency, biogenesis, maintenance and inheritance of this dynamic cellular compartment. Several peroxisome-associated proteins have been identified, which mediate interaction with motor proteins, adaptor proteins or other constituents of the cytoskeleton. It appears that there is a species-specific complexity of protein-protein interactions required to control directional movement and arresting. An open question is why some proteins with a specific role in peroxisomal protein import have an additional function in the regulation of cytoskeleton binding and motility of peroxisomes.

KEYWORDS:

Actin filaments; Cytoskeleton; Microtubules; Motor proteins; Peroxins; Peroxisome motility

PMID:
26616035
DOI:
10.1016/j.bbamcr.2015.11.022
[Indexed for MEDLINE]
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