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Headache. 2016 Feb;56(2):240-58. doi: 10.1111/head.12729. Epub 2015 Nov 30.

The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache.

Author information

1
Montefiore Headache Center, Bronx, NY, USA.
2
Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
3
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
4
The Kaplan Headache Center, Optimum Health Medical Group, PLLC, Clifton Park, NY, USA.
5
Department of Neurology, Medstar Georgetown University Medical Center, Washington, DC, USA.
6
Department of Neurology, University of Michigan Health System, Ann Arbor, MI, USA.
7
Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
8
The Headache Center of Southern California, Encinitas, CA, USA.
9
Pain and Headache Center, Cushing Neuroscience Institute, Department of Neurology, Hofstra North Shore LIJ Medical Center, Manhasset, NY, USA.
10
The Neurology Center, Silver Spring, MD, USA.
11
Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
12
Carolina Headache Institute, Durham, NC, USA.
13
Department of Medicine (Neurology), Doylestown Hospital, Doylestown, PA, USA.

Abstract

The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.

KEYWORDS:

ablation; cluster; ganglion; headache; migraine; neuralgia; neurostimulation; pterygopalatine; sphenopalatine

PMID:
26615983
DOI:
10.1111/head.12729
[Indexed for MEDLINE]

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