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Curr Opin Struct Biol. 2015 Dec;35:93-9. doi: 10.1016/j.sbi.2015.10.002. Epub 2015 Nov 23.

The framework of polysaccharide monooxygenase structure and chemistry.

Author information

1
Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, United States.
2
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, United States; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, United States. Electronic address: marletta@berkeley.edu.

Abstract

Polysaccharide monooxygenases, or PMOs (also known as lytic PMOs or LPMOs), are a group of enzymes discovered in recent years to catalyze the oxidative degradation of carbohydrate polymers. The PMO catalytic domain has a β-sandwich fold that bears a strong resemblance to both immunoglobulin (Ig) and fibronectin type III (FnIII) domains. PMOs are secreted by fungi and bacteria, and there is recent evidence for their roles in pathogenesis, in addition to biomass processing. This review addresses the biological origins and functions of emerging PMO families, as well as describes the aspects of PMO structure that support the chemistry of copper-catalyzed, oxidative polysaccharide degradation.

PMID:
26615470
DOI:
10.1016/j.sbi.2015.10.002
[Indexed for MEDLINE]

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