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Tumour Biol. 2016 May;37(5):6191-6. doi: 10.1007/s13277-015-4435-6. Epub 2015 Nov 28.

Association between interleukin 8 -251 A/T and +781 C/T polymorphisms and osteosarcoma risk in Chinese population: a case-control study.

Author information

1
Department of Orthopaedics Institute, Tianjin Hospital, No. 406 Jiefangnan Street, Tianjin, 300211, China.
2
Department of Orthopaedics, The Third Affiliated Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, 050051, China.
3
Department of Orthopaedics Institute, Tianjin Hospital, No. 406 Jiefangnan Street, Tianjin, 300211, China. dongjingming_tj@sina.com.
4
Department of Oncology, Peking University Cancer Hospital, No. 52, Fucheng Road, Beijing, 100142, China. guoqian_tj@sina.com.

Abstract

Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies. However, there are no data about the role of IL-8 polymorphism in development of osteosarcoma. A hospital-based case-control study was conducted among 190 patients with osteosarcoma and 190 healthy controls to investigate the possible association between the IL-8 -251 A/T and +781 C/T polymorphisms, respectively, and the risk of osteosarcoma. Significant differences of genotype distribution were observed between osteosarcoma cases and controls at the IL-8 -251T/A genotypes. Compared with the IL-8 -251T/A homozygote TT, the heterozygous TA genotype was associated with significantly increased risk for osteosarcoma (odds ratio (OR) = 2.16, 95 % confidence interval (CI) = (1.38-4.52), P = 0.021); the AA genotype was associated with increased risk for osteosarcoma (OR = 1.94, 95 % CI = 1.31-3.83, P = 0.018). TA and AA combined variants were associated with increased risk for osteosarcoma compared with the TT genotype (OR = 1.72, 95 % CI = 1.45-4.41, P = 0.023). Moreover, the genotype AA of IL-8 -251T/A carried a higher risk of osteosarcoma metastasis and later Enneking stages, compared with the TT genotype. However, the genotype and allele frequencies of IL-8 +781 C/T polymorphisms in osteosarcoma patients were not significantly different from controls. Our results showed that the IL-8 -251 A/T genotype was associated with increased risk for development and metastasis of osteosarcoma in Chinese Han population.

KEYWORDS:

IL-8; Osteosarcoma; Single-nucleotide polymorphism; Susceptibility

PMID:
26615418
DOI:
10.1007/s13277-015-4435-6
[Indexed for MEDLINE]

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