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J Clin Virol. 2016 Jan;74:1-3. doi: 10.1016/j.jcv.2015.11.014. Epub 2015 Nov 23.

First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil.

Author information

1
Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: guilherme.calvet@ini.fiocruz.br.
2
Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: abispo@ioc.fiocruz.br.
3
Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: marcosclm@ioc.fiocruz.br.
4
Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: patricia@ioc.fiocruz.br.
5
Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: andre.siqueira@ini.fiocruz.br.
6
STD/AIDS Clinical Research Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: valdilea.veloso@gmail.com.
7
Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: rita@ioc.fiocruz.br.
8
Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: patricia.brasil@ini.fiocruz.br.

Abstract

Since May 2015, Brazil's Ministry of Health has reported autochthonous transmission of Zika virus (ZIKV) in some states of the country. Simultaneous circulation of Dengue, Chikungunya and ZIKV in the country hinder both the diagnosis and the therapeutic approach of patients seeking care with acute febrile illnesses especially in patients with comorbidities. The association between HIV infection and endemic diseases has been described especially in tropical regions with varying levels of complications, although there has been no report of ZIKV in HIV-infected patients. We report the first autochthonous case of laboratory confirmed ZIKV infection in a HIV-infected patient in Rio de Janeiro, Brazil. He evolved with only mild symptoms and recovered well without major laboratory abnormalities. Phylogenetic analysis of the ZIKV detected in the patient sera clustered within the Asian clade. To the best of our knowledge, this is the first time that Zika virus co-infection is reported in a HIV-infected patient.

KEYWORDS:

Arbovirus; Brazil; HIV; ZIKV; Zika

PMID:
26615388
DOI:
10.1016/j.jcv.2015.11.014
[Indexed for MEDLINE]

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