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Hautarzt. 1989 May;40(5):290-5.

[Demonstration of S 100 protein in malignant melanoma of the skin. Pattern of distribution and significance for determination of tumor thickness].

[Article in German]

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Abteilung Dermatologie I (Allgemeine Dermatologie mit Poliklinik), Universitäts-Hautklinik Tübingen.


Paraffin sections of 110 histologically proven malignant melanomas were incubated with a polyclonal antibody against S-100-protein. The avidin-biotin-peroxidase technique was used. A positive reaction was found in 109 cases. The staining pattern was inhomogeneous, suggesting heterogeneity within the tumor. The tumor thickness was measured in HE sections and corresponding sections that had been incubated with an antibody against S-100 protein. The results were as follows: 48.5% of the melanomas incubated with anti-S-100 protein showed a greater tumor thickness than the HE sections. The deviation between the two criteria was 15%. Four cases with the histological diagnosis of "melanoma in situ" showed S-100-positive cells within the subepidermal inflammatory infiltrate. Incubating sections of malignant melanoma with anti-S-100-protein facilitates the recognition of neoplastic cells within the inflammatory infiltrate.

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