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Biochem Soc Trans. 2015 Dec;43(6):1253-8. doi: 10.1042/BST20150167.

Ccr4-Not is at the core of the eukaryotic gene expression circuitry.

Author information

1
Department of Microbiology and Molecular Medicine, University of Geneva, Faculty of Medicine, 1 Rue Michel-Servet, 1206 Geneva, Switzerland.
2
Department of Microbiology and Molecular Medicine, University of Geneva, Faculty of Medicine, 1 Rue Michel-Servet, 1206 Geneva, Switzerland Martine.Collart@unige.ch.

Abstract

In this mini-review, we summarize our current knowledge about the cross-talk between the different levels of gene expression. We introduce the Ccr4 (carbon catabolite repressed 4)-Not (negative on TATA-less) complex as a candidate to be a master regulator that orchestrates between the different levels of gene expression. An integrated view of the findings about the Ccr4-Not complex suggests that it is involved in gene expression co-ordination. Since the discovery of the Not proteins in a selection for transcription regulators in yeast [Collart and Struhl (1994) Genes Dev. 8: , 525-537], the Ccr4-Not complex has been connected to every step of the mRNA lifecycle. Moreover, it has been found to be relevant for appropriate protein folding and quaternary protein structure by being involved in co-translational protein complex assembly.

KEYWORDS:

Ccr4–Not; co-translational complex assembly; gene expression buffering; gene expression circuitry; messenger ribonucleic acid (mRNA) imprinting; protein homoeostasis

PMID:
26614669
DOI:
10.1042/BST20150167
[Indexed for MEDLINE]

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