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Neurol Clin. 2016 Feb;34(1):171-81. doi: 10.1016/j.ncl.2015.08.007.

Frontotemporal Dementia.

Author information

1
Department of Neurology, Tulane University School of Medicine, 1430 Tulane Avenue, 8065, New Orleans, LA 70112, USA. Electronic address: rkelley2@tulane.edu.
2
Department of Neurology, Tulane University School of Medicine, 1430 Tulane Avenue, 8065, New Orleans, LA 70112, USA.

Abstract

Frontotemporal dementia (FTD) is a not-uncommon explanation for progressive cognitive deficit in patients who often have a genetic susceptibility for such a neurodegenerative process. However, FTD does not seem to identify one particular pathogenetic mechanism but rather a spectrum of pathologies with particular predilection for the frontal and temporal lobes of the brain. There have been various subcategorizations of this form of dementia that have a tendency to be of earlier onset than typical Alzheimer disease and heralded by behavioral or communication manifestations. There is a behavioral variant and a language variant, referred to as primary progressive aphasia.

KEYWORDS:

Abulia; Aphasia neurodegenerative disorder; Behavioral disturbance; Dementia; Disinhibition; Impulsivity; Inattention

PMID:
26613998
PMCID:
PMC5549462
DOI:
10.1016/j.ncl.2015.08.007
[Indexed for MEDLINE]
Free PMC Article

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