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Curr Genet. 2016 May;62(2):313-5. doi: 10.1007/s00294-015-0546-2. Epub 2015 Nov 27.

Post-transcriptional regulation in budding yeast meiosis.

Author information

1
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA.
2
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA. aaron.neiman@stonybrook.edu.

Abstract

The precise regulation of gene expression is essential for developmental processes in eukaryotic organisms. As an important post-transcriptional regulatory point, translational control is complementary to transcriptional regulation. Sporulation in the budding yeast Saccharomyces cerevisiae is a developmental process controlled by a well-studied transcriptional cascade that drives the cell through the events of DNA replication, meiotic chromosome segregation, and spore assembly. Recent studies have revealed that as cells begin the meiotic divisions, translational regulation of gene expression fine tunes this transcriptional cascade. The significance and mechanisms of this translational regulation are beginning to emerge. These studies may also provide insights into translational regulation in germ cell development of multicellular organisms.

KEYWORDS:

Development program; Gene expression; Sporulation; Translational control; mRNA localization

PMID:
26613728
PMCID:
PMC4826848
DOI:
10.1007/s00294-015-0546-2
[Indexed for MEDLINE]
Free PMC Article

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