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Mediators Inflamm. 2015;2015:497387. doi: 10.1155/2015/497387. Epub 2015 Nov 3.

Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.

Author information

1
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA ; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
2
Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA ; Biochemistry Program, Washington University School of Medicine, St. Louis, MO 63110, USA ; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA ; Drug Discovery Program in Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
3
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA ; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA.
4
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA ; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA ; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA ; Drug Discovery Program in Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.

PMID:
26612971
PMCID:
PMC4647060
DOI:
10.1155/2015/497387
[Indexed for MEDLINE]
Free PMC Article

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