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Nat Cell Biol. 2015 Dec;17(12):1515-7. doi: 10.1038/ncb3278.

Rethinking glutamine addiction.

Author information

1
UCLA, Molecular and Medical Pharmacology, 34-115 Center for Health Sciences, 650 Charles E. Young Drive South, Los Angeles, California 90095, USA.

Abstract

Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.

PMID:
26612572
DOI:
10.1038/ncb3278
[Indexed for MEDLINE]

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