Format

Send to

Choose Destination
Clin Infect Dis. 2016 Mar 1;62(5):531-6. doi: 10.1093/cid/civ975. Epub 2015 Nov 26.

Home Screening for Bacterial Vaginosis to Prevent Sexually Transmitted Diseases.

Author information

1
Department of Medicine, University of Alabama at Birmingham.
2
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock.
3
San Francisco Department of Public Health, California.
4
Department of Obstetrics and Gynecology, Magee-Women's Hospital of University of Pittsburgh Medical Center, Pennsylvania.
5
Department of Medicine, University of North Carolina at Chapel Hill.
6
Family Health International, Durham, North Carolina.
7
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
8
Departments of Epidemiology and Medicine, University of Florida, Gainesville.

Abstract

BACKGROUND:

Longitudinal studies have consistently found a significant association between bacterial vaginosis (BV) and acquisition of sexually transmitted diseases. However, there are limited prospective data to confirm these findings.

METHODS:

We conducted a prospective, randomized, open-label trial of home screening and treatment of young women with asymptomatic BV who were also at high risk for sexually transmitted diseases. These women were screened every 2 months for 12 months and randomized to treatment with oral metronidazole 500 mg twice daily for 7 days or observation alone. The primary outcome was the incidence of gonorrhea and/or chlamydia.

RESULTS:

A total of 1365 subjects were enrolled in the study across 10 sites. Adherence with mailing specimens obtained at home was excellent in both groups (84%-88%). The incidence of gonorrhea and/or chlamydia was 19.1 per 100 person-years (95% confidence interval, 15.1-22.1) for the treatment group and 18.5 per 100 person-years (15.1-22.8) for the observation arm, a difference that was not statistically significant.

CONCLUSIONS:

Young women were very amenable to home screening for BV, gonorrhea, and chlamydia. Treatment of asymptomatic BV with 1 week of oral metronidazole did not decrease the incidence of gonorrhea and/or chlamydia.

CLINICAL TRIALS REGISTRATION:

NCT00667368.

KEYWORDS:

STD; bacterial vaginosis; home screening

PMID:
26611782
PMCID:
PMC4741364
[Available on 2017-03-01]
DOI:
10.1093/cid/civ975
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center