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Rev Mal Respir. 2015 Dec;32(10):1072-81. doi: 10.1016/j.rmr.2015.09.007. Epub 2015 Nov 21.

Adaptive servo-ventilation: How does it fit into the treatment of central sleep apnoea syndrome? Expert opinions.

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Inserm 1063, département de pneumologie, CHU d'Angers, université d'Angers, 49000 Angers, France.
Service de physiologie - explorations fonctionnelles, DHU FIRE, hôpital Bichat, GHUPNVS, AP-HP, université Denis-Diderot, Sorbonne Paris Cité, 75018 Paris, France.
Inserm U955, équipe 8, service de cardiologie, hôpital Henri-Mondor, 94000 Créteil, France.
U1046 Inserm - UMR9214 CNRS - PhyMedExp, département de cardiologie et maladies vasculaires, CHU de Montpellier, université de Montpellier, 34000 Montpellier, France.
Service de pneumologie, centre La Louvière, 69, rue de la Louvière, 59000 Lille, France.
Service de pneumologie, CHU de Poitiers, université de Poitiers, 2, rue de la Milétrie, 86000 Poitiers, France. Electronic address:
Inserm U1042, pôle thorax et vaisseaux, secteur physiologie sommeil et exercice, laboratoire EFCR, CHU de Grenoble, université Grenoble Alpes, HP2, 38000 Grenoble, France.
Service de pathologies du sommeil, département R3S, groupe hospitalier Pitié-Salpêtrière-Charles-Foix, AP-HP, 75013 Paris, France.


The preliminary results of the SERVE-HF study have led to the release of safety information with subsequent contraindication to the use of adaptive servo-ventilation (ASV) for the treatment of central sleep apnoeas in patients with chronic symptomatic systolic heart failure with left ventricular ejection fraction (LVEF) ≤ 45%. The aim of this article is to review these results, and to provide more detailed arguments based on data from the literature advocating the continued use of ASV in different indications, including heart failure with preserved LVEF, complex sleep apnoea syndrome, opioid-induced central sleep apnea syndrome, idiopathic central SAS, and central SAS due to a stroke. Based on these findings, we propose to set up registers dedicated to patients in whom ASV has been stopped and in the context of the next setting up of ASV in these specific indications to ensure patient safety and allow reasoned decisions on the use of ASV.


Adaptive servo-ventilation; Central sleep apnoea syndrome; Heart failure; Insuffisance cardiaque; Syndrome des apnées du sommeil central; Ventilation auto-asservie

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