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Int J Mol Sci. 2015 Nov 24;16(11):27978-87. doi: 10.3390/ijms161126071.

Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.

Author information

1
Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. wanfeier@live.cn.
2
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. juan_wang2012@163.com.
3
School of Public Health, Jilin University, Changchun 130021, China. juan_wang2012@163.com.
4
Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. zjj523@126.com.
5
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. kobe24song@126.com.
6
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. faiku2010@hkbu.edu.hk.
7
Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. zoujuan-729@163.com.
8
Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. lijixinmylove@yeah.net.
9
Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. lijun@uic.edu.
10
Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. ltpan@sina.cn.
11
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. zhanghj@hkbu.edu.hk.

Abstract

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 ┬ÁM (SI = 12.2).

KEYWORDS:

Pteris henryi; anti-HIV activity; bioactivity evaluation; ent-kaurane diterpene; henrin A

PMID:
26610490
PMCID:
PMC4661929
DOI:
10.3390/ijms161126071
[Indexed for MEDLINE]
Free PMC Article

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