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Future Microbiol. 2015;10(12):2033-43. doi: 10.2217/fmb.15.114. Epub 2015 Nov 19.

Emerging horizons for tick-borne pathogens: from the 'one pathogen-one disease' vision to the pathobiome paradigm.

Author information

1
INRA, UMR BIPAR, INRA, ANSES, ENVA Maisons-Alfort, France.
2
Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia.
3
Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic.
4
Department of Parasitology & Zoology, Faculty of Veterinary Science, Szent István University, Budapest, Hungary.
5
INRA, UR 346 Epidémiologie Animale, Saint Genès Champanelle, France.
6
University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca, Department of Parasitology & Parasitic Diseases, Cluj-Napoca, Romania.
7
INRA, UMR 1300 BioEpAR, Nantes, France.
8
National Centre for Vector Entomology, Institute of Parasitology, Vetsuisse-Faculty, University of Zurich, Zürich, Switzerland.
9
University of East London, School of Health, Sport & Bioscience, London, UK.
10
Fondazione Edmund Mach, Research & Innovation Centre, San Michele all'Adige, Trento, Italy.

Abstract

Ticks, as vectors of several notorious zoonotic pathogens, represent an important and increasing threat for human and animal health in Europe. Recent applications of new technology revealed the complexity of the tick microbiome, which may affect its vectorial capacity. Appreciation of these complex systems is expanding our understanding of tick-borne pathogens, leading us to evolve a more integrated view that embraces the 'pathobiome'; the pathogenic agent integrated within its abiotic and biotic environments. In this review, we will explore how this new vision will revolutionize our understanding of tick-borne diseases. We will discuss the implications in terms of future research approaches that will enable us to efficiently prevent and control the threat posed by ticks.

KEYWORDS:

Ixodes ricinus; co-infections; emerging diseases; new paradigm; next-generation sequencing; pathobiome; unknown pathogens; vector competence; zoonoses

PMID:
26610021
PMCID:
PMC4944395
DOI:
10.2217/fmb.15.114
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

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