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Curr Opin Immunol. 2016 Apr;39:1-6. doi: 10.1016/j.coi.2015.10.009. Epub 2015 Nov 21.

Immune suppressive mechanisms in the tumor microenvironment.

Author information

1
Georgia Regents University Cancer Center and the Medical College of Georgia, Augusta GA 30192, USA. Electronic address: dmunn@gru.edu.
2
University Hospital and Department of Medicine, University of Verona, 37134, Italy. Electronic address: vincenzo.bronte@univr.it.

Abstract

Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells. These often display inducible suppressive mechanisms that are triggered by the same anti-tumor inflammatory response that the immunotherapy intends to create. Therefore, a more comprehensive understanding of how the immunosuppressive milieu develops and persists is critical in order to harness the full power of immunotherapy of cancer.

PMID:
26609943
PMCID:
PMC5627973
DOI:
10.1016/j.coi.2015.10.009
[Indexed for MEDLINE]
Free PMC Article

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