Format

Send to

Choose Destination
Biomark Med. 2016;10(2):185-95. doi: 10.2217/bmm.15.113. Epub 2015 Nov 26.

Clinical significance of IL-2 and IL-10 gene polymorphisms and serum levels in patients with basal-cell carcinoma.

Author information

1
Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland.
2
Department of Pediatrics, Hematology & Oncology, Medical University of Gdansk, Poland.
3
Department of Pathology & Experimental Rheumatology, Medical University of Gdansk, Poland.

Abstract

MATERIALS & METHODS:

Polymorphic variants of IL-2 gene (-330 T/G and +166 G/T), IL-10 gene (-1082 G/A and -819 C/T) and serum cytokines concentrations in the group of 179 patients with BCC and 173 controls were analyzed.

RESULTS:

The presence of the IL-2 -330 GG genotype or IL-10 -1082 GA increased the risk of BCC (OR 3.68) (OR 3.07). IL-10 -1082 AA or GA and IL-2 -330 GG genotype increased the risk of BCC (OR 9.63). IL-2 serum levels were significantly lower (p < 0.0004) in BCC patients while IL-10 concentration was significantly higher (p < 0.00001).

CONCLUSION:

The polymorphisms in IL-2 and IL-10 genes may contribute to BCC susceptibility and influence the clinical course of BCC in polish population.

KEYWORDS:

BC; IL-10; IL-2; basal-cell carcinoma; gene polymorphism; interleukin serum concentrations

PMID:
26609634
DOI:
10.2217/bmm.15.113
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center