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Bone. 2016 Feb;83:197-209. doi: 10.1016/j.bone.2015.11.011. Epub 2015 Nov 19.

Tissue engineering strategies for promoting vascularized bone regeneration.

Author information

1
Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States; UCSF-UCB Masters of Translational Medicine Program, Berkeley and San Francisco, CA, United States.
2
Departments of Bioengineering, and Material Science and Engineering, University of California, Berkeley (UCB), Berkeley, CA, United States.
3
Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States.
4
Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States; Departments of Bioengineering, and Material Science and Engineering, University of California, Berkeley (UCB), Berkeley, CA, United States. Electronic address: Chelsea.Bahney@UCSF.edu.

Abstract

This review focuses on current tissue engineering strategies for promoting vascularized bone regeneration. We review the role of angiogenic growth factors in promoting vascularized bone regeneration and discuss the different therapeutic strategies for controlled/sustained growth factor delivery. Next, we address the therapeutic uses of stem cells in vascularized bone regeneration. Specifically, this review addresses the concept of co-culture using osteogenic and vasculogenic stem cells, and how adipose derived stem cells compare to bone marrow derived mesenchymal stem cells in the promotion of angiogenesis. We conclude this review with a discussion of a novel approach to bone regeneration through a cartilage intermediate, and discuss why it has the potential to be more effective than traditional bone grafting methods.

KEYWORDS:

Angiogenesis; Bone regeneration; Controlled release; Endochondral ossification; Osteogenesis; Stem cells

PMID:
26608518
PMCID:
PMC4911893
DOI:
10.1016/j.bone.2015.11.011
[Indexed for MEDLINE]
Free PMC Article

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