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Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G143-54. doi: 10.1152/ajpgi.00215.2015. Epub 2015 Nov 25.

The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis.

Author information

1
Curtin Health Innovation Research Institute, Curtin University, Perth Western Australia, Australia;
2
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine and Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia;
3
Curtin Health Innovation Research Institute, Curtin University, Perth Western Australia, Australia; Fiona Stanley and Fremantle Hospitals, Western Australia, Australia; School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia; and.
4
Curtin Health Innovation Research Institute, Curtin University, Perth Western Australia, Australia; School of Medicine and Pharmacology, University of Western Australia, Fremantle Western Australia, Australia N.Tirnitz-Parker@curtin.edu.au.

Abstract

The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the metabolic syndrome has sparked interest in stem cell-like liver progenitor cells (LPCs) as potential candidates for cell therapy and tissue engineering, as an alternative approach to whole organ transplantation. However, LPCs always proliferate in chronic liver diseases with a predisposition to cancer; they have been suggested to play major roles in driving fibrosis, disease progression, and may even represent tumor-initiating cells. Hence, a greater understanding of the factors that govern their activation, communication with other hepatic cell types, and bipotential differentiation as opposed to their potential transformation is needed before their therapeutic potential can be harnessed.

KEYWORDS:

carcinogenesis; chronic liver disease; fibrosis; liver progenitor cells; liver regeneration

PMID:
26608186
DOI:
10.1152/ajpgi.00215.2015
[Indexed for MEDLINE]
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