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FEBS Lett. 2015 Dec 21;589(24 Pt B):4053-60. doi: 10.1016/j.febslet.2015.11.020. Epub 2015 Nov 19.

Global DNA hypomethylation coupled to cellular transformation and metastatic ability.

Author information

1
Department of Pathology, Osaka University, Osaka 565-0871, Japan; Department of General Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
2
Nagahama Institute of Bio-Science and Technology, Shiga 526-0829, Japan; JST, CREST, Saitama 332-0012, Japan. Electronic address: tnakamura@nagahama-i-bio.ac.jp.
3
Department of Pathology, Osaka University, Osaka 565-0871, Japan.
4
Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan.
5
Department of General Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
6
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
7
Department of Pathology, Osaka University, Osaka 565-0871, Japan; JST, CREST, Saitama 332-0012, Japan; Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan. Electronic address: tnakano@patho.med.osaka-u.ac.jp.

Abstract

Global DNA hypomethylation and DNA hypermethylation of promoter regions are frequently detected in human cancers. Although many studies have suggested a contribution to carcinogenesis, it is still unclear whether the aberrant DNA hypomethylation observed in tumors is a consequence or a cause of cancer. Here, we show that the enforced expression of Stella (also known as PGC7 and Dppa3) induced not only global DNA demethylation but also transformation of NIH3T3 cells. Furthermore, overexpression of Stella enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes. These results provide new insights into the function of global DNA hypomethylation in carcinogenesis.

KEYWORDS:

DNA hypomethylation; Metastasis; Stella; Transformation

PMID:
26608031
DOI:
10.1016/j.febslet.2015.11.020
[Indexed for MEDLINE]
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