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Am J Clin Nutr. 2016 Jan;103(1):192-200. doi: 10.3945/ajcn.115.121145. Epub 2015 Nov 25.

Associations of red and processed meat with survival after colorectal cancer and differences according to timing of dietary assessment.

Author information

1
Divisions of Clinical Epidemiology and Aging Research.
2
Departments of Applied Tumor Biology and.
3
Unit of Molecular Tumor Pathology; and Pathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; and.
4
Institute of Pathology, Charité University Medicine, Berlin, Germany.
5
Cancer Epidemiology, and.
6
Divisions of Clinical Epidemiology and Aging Research, Preventive Oncology; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany;
7
Divisions of Clinical Epidemiology and Aging Research, m.hoffmeister@dkfz.de.

Abstract

BACKGROUND:

Little is known about the prognostic impact of red and processed meat intake or about changes in consumption after a diagnosis of colorectal cancer (CRC).

OBJECTIVES:

We investigated associations of baseline red and processed meat with survival outcomes and explored changes in intake among CRC survivors 5 y after diagnosis.

DESIGN:

A total of 3122 patients diagnosed with CRC between 2003 and 2010 were followed for a median of 4.8 y [DACHS (Darmkrebs: Chancen der Verhütung durch Screening) study]. Patients provided information on diet and other factors in standardized questionnaires at baseline and at the 5-y follow-up. Cox proportional hazards regression models were used to estimate HRs and 95% CIs.

RESULTS:

Among patients with stage I-III CRC, baseline red and processed meat intake was not associated with overall (>1 time/d compared with <1 time/d; HR: 0.85; 95% CI: 0.67, 1.09), CRC-specific (HR: 0.83; 95% CI: 0.61, 1.14), cardiovascular disease-specific (HR: 0.92; 95% CI: 0.51, 1.68), non-CRC-specific (HR: 0.88; 95% CI: 0.59, 1.30), and recurrence-free (HR: 1.03; 95% CI: 0.80, 1.33) survival; results among stage IV patients were comparable. An association with worse overall survival was found among patients with Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated CRC (HR: 1.99; 95% CI: 1.10, 3.56) but not with microsatellite instability or CpG island methylator phenotype (CIMP) positivity. A much lower proportion of survivors reported daily consumption of red and processed meat at the 5-y follow-up than at baseline (concordance rate: 39%; κ-value: 0.10; 95% CI: 0.07, 0.13).

CONCLUSIONS:

Our findings suggest that baseline red and processed meat intake is not associated with poorer survival among patients with CRC. The potential interaction with KRAS mutation status warrants further evaluation. Major changes in consumption measured at the 5-y follow-up may have had an impact on our survival estimates.

KEYWORDS:

colorectal cancer; molecular subtypes; mortality; red and processed meat; survival

PMID:
26607936
DOI:
10.3945/ajcn.115.121145
[Indexed for MEDLINE]

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