3D Biomaterial Microarrays for Regenerative Medicine: Current State-of-the-Art, Emerging Directions and Future Trends

Adv Mater. 2016 Jan 27;28(4):771-81. doi: 10.1002/adma.201503918. Epub 2015 Nov 26.

Abstract

Three dimensional (3D) biomaterial microarrays hold enormous promise for regenerative medicine because of their ability to accelerate the design and fabrication of biomimetic materials. Such tissue-like biomaterials can provide an appropriate microenvironment for stimulating and controlling stem cell differentiation into tissue-specific lineages. The use of 3D biomaterial microarrays can, if optimized correctly, result in a more than 1000-fold reduction in biomaterials and cells consumption when engineering optimal materials combinations, which makes these miniaturized systems very attractive for tissue engineering and drug screening applications.

Keywords: 3D microarrays; 3D printing; biomaterials; microfabrication; tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials / chemistry*
  • Cell Differentiation / drug effects
  • Cell Survival
  • Embryonic Stem Cells / cytology
  • Extracellular Matrix Proteins / chemistry
  • High-Throughput Screening Assays
  • Humans
  • Microarray Analysis / instrumentation
  • Microarray Analysis / methods*
  • Regenerative Medicine*
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / toxicity
  • Tissue Engineering
  • Tissue Scaffolds

Substances

  • Extracellular Matrix Proteins
  • Small Molecule Libraries