Format

Send to

Choose Destination
Am J Hematol. 2016 Jan;91(1):151-65. doi: 10.1002/ajh.24233. Epub 2015 Nov 26.

Cutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management.

Author information

1
Division of Hematology/Oncology, University of Michigan Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan.

Abstract

DISEASE OVERVIEW:

Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).

DIAGNOSIS:

The diagnosis of MF or SS requires the integration of clinical and histopathologic data.

RISK-ADAPTED THERAPY:

TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multidisciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin-directed therapies is preferred, as both disease-specific and overall survival for these patients is favorable. In contrast, patients with advanced-stage disease with significant nodal, visceral, or blood involvement are generally approached with biologic-response modifiers or histone deacetylase inhibitors before escalating therapy to include systemic, single-agent chemotherapy. In highly-selected patients, allogeneic stem-cell transplantation may be considered, as this may be curative in some patients.

PMID:
26607183
PMCID:
PMC4715621
DOI:
10.1002/ajh.24233
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center