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Ann Transl Med. 2015 Oct;3(17):256. doi: 10.3978/j.issn.2305-5839.2015.09.45.

Strategies for functional bioscaffold-based skeletal muscle reconstruction.

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1
1 McGowan Institute for Regenerative Medicine, 2 Department of Surgery, 3 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

Tissue engineering and regenerative medicine-based strategies for the reconstruction of functional skeletal muscle tissue have included cellular and acellular approaches. The use of acellular biologic scaffold material as a treatment for volumetric muscle loss (VML) in five patients has recently been reported with a generally favorable outcome. Further studies are necessary for a better understanding of the mechanism(s) behind acellular bioscaffold-mediated skeletal muscle repair, and for combination cell-based/bioscaffold based approaches. The present overview highlights the current thinking on bioscaffold-based remodeling including the associated mechanisms and the future of scaffold-based skeletal muscle reconstruction.

KEYWORDS:

Tissue engineering; bioscaffolds; extracellular matrix (ECM); regenerative medicine; skeletal muscle reconstruction; volumetric muscle loss (VML)

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