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Patient Prefer Adherence. 2015 Nov 3;9:1561-72. doi: 10.2147/PPA.S90425. eCollection 2015.

Health state utility valuation in radioactive iodine-refractory differentiated thyroid cancer.

Author information

1
ICON Patient Reported Outcomes, Oxford, UK.
2
ICON Epidemiology, Toronto, ON, Canada.
3
Eisai Inc., NJ, USA.
4
Moffitt Cancer Center, FL, USA.
5
University of California San Diego Moores Cancer Center, La Jolla, CA, USA.

Abstract

PURPOSE:

The aim of this study was to elicit utilities for radioactive iodine-refractory differentiated thyroid cancer (RR-DTC) and evaluate the impact of treatment response and toxicities on quality of life.

PATIENTS AND METHODS:

RR-DTC health states were developed based on data from a previous qualitative study and iterative review by clinical experts. Following piloting, health states underwent valuation by 100 members of the UK public during time trade-off interviews. Mean utilities and descriptive distribution statistics were calculated, and a logistic regression analysis was conducted.

RESULTS:

The demographic characteristics of the study sample were generally reflective of the UK population. Clear differentiation in valuation between health states was observed. No response/stable disease had an adjusted utility value of 0.87, with a corresponding gain of +0.04 following a treatment response and a decline of -0.35 for disease progression. Adverse events were associated with utility decrements between -0.47 (grade III diarrhea) and -0.05 (grade I/II alopecia).

CONCLUSION:

The trade-off interviews derived utility weights show clear differentiation between RR-DTC health states in response to treatment. The values reported in this study are suitable for cost-effectiveness evaluations for new treatments in RR-DTC.

KEYWORDS:

differentiated thyroid cancer; health utility; health-related quality of life; radioactive iodine-refractory; vignette

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