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J Pharmacol Sci. 2015 Nov;129(3):200-4. doi: 10.1016/j.jphs.2015.10.001. Epub 2015 Oct 13.

Angiostatin prevents IL-1β-induced down-regulation of eNOS expression by inhibiting the NF-κB cascade.

Author information

1
Department of Health Chemistry, School of Pharmacy, Iwate Medical University, Nishitokuta 2-1-1, Yahaba, Shiwa-gun, Iwate 028-3694, Japan. Electronic address: ykawasak@iwate-med.ac.jp.
2
Department of Health Chemistry, School of Pharmacy, Iwate Medical University, Nishitokuta 2-1-1, Yahaba, Shiwa-gun, Iwate 028-3694, Japan.

Abstract

This study aimed to elucidate the protective potential of angiostatin in inflamed endothelial cells in culture. We assessed the effect of angiostatin on the expression of ICAM-1 and eNOS. Angiostatin prevented IL-1β-induced down-regulation of eNOS expression, but produced no significant changes on IL-1β-induced up-regulation of ICAM-1. We then explored the effect of angiostatin on IL-1β-mediated inflammatory signaling and found that angiostatin inhibited IL-1β-mediated nuclear translocation of NF-κB. Thus, our results suggest that angiostatin prevents IL-1β-induced down-regulation of eNOS expression via inhibition of the NF-κB cascade; this may be the anti-inflammatory mechanism of angiostatin.

KEYWORDS:

Angiostatin; Anti-inflammatory; Endothelial nitric oxide synthase (eNOS)

PMID:
26603529
DOI:
10.1016/j.jphs.2015.10.001
[Indexed for MEDLINE]
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