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Sci Rep. 2015 Nov 25;5:17281. doi: 10.1038/srep17281.

Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa.

Author information

1
Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.
2
Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.
3
Department of Pediatric Pneumology and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
4
Clinic and Polyclinic for Pediatrics and Adolescent Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
5
Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
6
Département de Parasitologie, Université des Sciences de la Santé, Libreville, Gabon.
7
Ngounie Medical Research Centre, Fougamou, Gabon.
8
ISGlobal, Barcelona Ctr. Int. Health Res (CRESIB), Hospital Clínic- Universitat de Barcelona), Barcelona, Spain.

Abstract

Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based on capsular epitopes will relate to local epidemiology of S. agalactiae serotypes and successful management of critical infections depends on timely therapy with effective antibiotics. This is the first report on serotype distribution and antimicrobial susceptibility of S. agalactiae in pregnant women from a Central African region. Serotypes V, III, and Ib accounted for 88/109 (81%) serotypes and all isolates were susceptible to penicillin and clindamycin while 13% showed intermediate susceptibility to erythromycin.

PMID:
26603208
PMCID:
PMC4658565
DOI:
10.1038/srep17281
[Indexed for MEDLINE]
Free PMC Article

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